After joining Hunan University:

[People of our research group have their names colored in green]  [Underlined authors contributed equally to the corresponding work]

[41] Tong Wu, Yuanyuan Chen, Steven C. Zimmerman*, Hang Xing* and Yugang Bai*, Goals, Challenges, and Perspectives in Chemical Transformations within Living Systems. Cell Rep. Phys. Sci. 2024, 5, 101896. [Link]

[40] Jiaqi Li, Yue Yu, Yu Zhou, Junfeng Song, Anming Yang, Min Wang, Youzhi Li, Muyang Wan, Chunhui Zhang, Huan Yang*, Yugang Bai*, Wing-Leung Wong*, Huangsheng Pu*, and Xinxin Feng*, Multi-Targeting Oligopyridiniums: Rational Design for Biofilm Dispersion and Bacterial Persister Eradication. Bioorg. Chem. 2024, 144, 107163. [Link]

[39] Ying Liu, Leyue Zhou, Xiang Xu, Zehong Cheng, Yajie Chen, Xue-Ao Mei, Nan Zheng*, Chunhui Zhang* and Yugang Bai*, Combination of Backbone Rigidity and Richness in Aryl Structures Enables Direct Membrane Translocation of Polymer Scaffold for Efficient Gene Delivery. Biomacromolecules 2023, 24, 5698-5706. [Link]

[38] Silei Bai, Junfeng Song, Huangsheng Pu*, Yue Yu, Wenwen Song, Zhiyong Chen, Min Wang, François-Xavier Campbell-Valois, Wing-Leung Wong, Qingyun Cai, Muyang Wan*, Chunhui Zhang*, Yugang Bai*, Xinxin Feng*, Chemical Biology Approach to Reveal the Importance of Precise Subcellular Targeting for Intracellular Staphylococcus aureus Eradication. J. Am. Chem. Soc. 2023, 145, 23372-23384. [Link]

[37] Ying Liu, Zhongwu Ren, Nannan Zhang, Xiaoxin Yang, Qihua Wu, Zehong Cheng, Hang Xing,* and Yugang Bai*, A Nanoscale MOF-Based Heterogeneous Catalytic System for the Polymerization of N-Carboxyanhydrides Enables Direct Routes toward Both Polypeptides and Related Hybrid Materials. Nat. Commun. 2023, 14, 5598. [Link]

[36] Yuanyuan Chen, Tong Wu, Shasha Xie, Yugang Bai* and Hang Xing*, Orientation-Controlled Membrane Anchoring of Bioorthogonal Catalysts on Live Cells via Liposome Fusion-based Transport. Sci. Adv. 2023, 9, eadg2583. [Link]

[35] Cailing Zhou, Yu Zhou, Yaqian Zheng, Yue Yu, Kailing Yang, Zhiyong Chen, Xianhui Chen, Kang Wen, Yajie Chen, Silei Bai, Junfeng Song, Tong Wu, E Lei, Muyang Wan, Qingyun Cai*, Luyan Z. Ma*, Wing-Leung Wong*, Yugang Bai*, Chunhui Zhang*, and Xinxin Feng*, An Amphiphilic Nano-sword for Direct Penetration and Eradication of Pathogenic Bacterial Biofilms. ACS Appl. Mater. Interface. 2023, 15, 20458-20473. [Link]

[34] Huan Wei, Zehong Cheng, Tong Wu, Yu Liu, Jing Guo, Ping-An Chen, Jiangnan Xia, Haihong Xie, Xincan Qiu, Tingting Liu, Bohan Zhang, Jingshu Hui, Zebing Zeng*, Yugang Bai*, Yuanyuan Hu*, Novel Organic Superbase Dopants for Ultraefficient n-Doping of Organic Semiconductors. Adv. Mater. 2023, 35, 2300084. [Link to the paper] Selected as Frontispiece, Adv. Mater. 2023, 35, 2370156 [Link to the Frontispiece cover image]

[33] Yingjiao Deng, Tong Wu*, Xianhui Chen, Yuanyuan Chen, Yating Fei, Ying Liu, Zhiyong Chen, Hang Xing and Yugang Bai*, A Membrane Embedded Macromolecular Catalyst with Substrate Selectivity in Live Cells. J. Am. Chem. Soc. 2023, 145, 1262-1272. (Front Cover) [Link]

[32] Zehong Cheng, Jing Guo, Jia Pan, Ying Liu, Huan Wei, Jishan Li, Song Liu,* Yuanyuan Hu,* and Yugang Bai*, Accelerated Preparation of Polypeptides and Related Hybrid Materials from A Disintegrable Initiator Array with Masked Carbenium Precursors. Chem. Mater. 2022, 34, 10732-10743. [Link]

[31] Zehong Cheng, Guokui Zheng, Ziqi Tian,* Xiangyu Chao, Yue Xiao, Jishan Li, and Yugang Bai*, Multivalency for Modularity: A Versatile Adhesive with Cooperatively Activated Fast Dismantlability. ACS Appl. Polym. Mater. 2022, 4, 6812-6816. [Link]

[30] Jing Guo, Ying Liu, Ping-An Chen, Xinhao Wang, Yanpei Wang, Jing Guo, Xincan Qiu, Zebing Zeng, Lang Jiang, Yuanping Yi, Shun Watanabe, Lei Liao, Yugang Bai*, Thuc-Quyen Nguyen*, Yuanyuan Hu*, Revealing the Electrophilic-Attack Doping Mechanism for Efficient and Universal p-doping of Organic Semiconductors. Adv. Sci. 2022, 9, 2203111. [Link]

[29] Xianhui Chen, Cailing Zhou, Jianxue Wang, Tong Wu, E Lei, Yi Wang, Guopu Huang, Yue Yu, Qingyun Cai,* Huangsheng Pu,* Xinxin Feng,* and Yugang Bai,* Improving the Hemocompatibility of Antimicrobial Peptidomimetics through Amphiphilicity Masking Using a Secondary Amphiphilic Polymer. Adv. Healthcare Mater. 2022, 11, 2200546. [Link]

[28] Guopu Huang, Hui Shen, Xianhui Chen, Tong Wu, Zhiyong Chen, Yajie Chen, Junfeng Song, Qingyun Cai,* Yugang Bai,* Huangsheng Pu* and Xinxin Feng*, A Degradable, Broad-Spectrum and Resistance-Resistant Antimicrobial Oligoguanidine as Disinfecting and Therapeutic Agent in Aquaculture. Polym. Chem. 2022, 13, 3539-3551. [Link]

[27] Zhiyong Chen, Wanqi Zhang, Yajie Chen, Yingjie Wang,* Silei Bai, Qingyun Cai, Huangsheng Pu,* Zuyong Wang,* Xinxin Feng* and Yugang Bai,* Alternatingly Amphiphilic Antimicrobial Oligoguanidines: Structure-Property Relationship and Usage as Coating Material with Unprecedented Hemocompatibility. Chem. Mater. 2022, 34, 3670–3682. [Link]

[26] Jianxue Wang, Junfeng Song, Xianhui Chen, Rey-Ting Guo, Yingjie Wang, Guopu Huang, Nan Zheng, Peilei Hu*, Xinxin Feng* and Yugang Bai,* Multivalent Display of Lipophilic DNA Binders for Dual-Selective Anti-Mycobacterium Peptidomimetics with Binary Mechanism of Action. CCS Chem. 2022, 4, 3573-3586. (Front Cover) [Link]

[25] Bohan Zhang, Silei Bai, Xiangyu Chao, Tong Wu, Zhiyong Chen, Zehong Cheng, Yue Xiao, Ke Zhang* and Yugang Bai,* Molecularly Pure Miktoarm Spherical Nucleic Acids: Preparation and Usage as Scaffold for Abiotic Intracellular Catalysis. Chem. Sci. 2021, 12, 15843-15848. (Back Cover) [Link]

[24] Yanhong Liu, Silei Bai, Tong Wu, Chun-Chi Chen, Ying Liu, Xiangyu Chao, Yugang Bai,* Dendronized Arm Snowflake Polymer as a Highly Branched Scaffold for Cellular Imaging and Delivery. Biomacromolecules 2021, 22, 3791–3799. [Link]

[23] Zhiyong Chen, Cailing Zhou, Yangfan Xu, Kang Wen, Junfeng Song, Silei Bai, Chenxuan Wu, Wei Huang, Qingyun Cai, Kai Zhou, Hui Wang, Yingjie Wang,* Xinxin Feng,* Yugang Bai*, An Alternatingly Amphiphilic, Resistance-Resistant Antimicrobial Oligoguanidine with Dual Mechanisms of Action. Biomaterials 2021, 275, 120858. [Link]

[22] Silei Bai, Jianxue Wang, Kailing Yang, Cailing Zhou, Yangfan Xu, Junfeng Song, Yuanxin Gu, Zheng Chen, Min Wang, Carolyn Shoen, Brenda Andrade, Michael Cynamon, Kai Zhou, Hui Wang, Qingyun Cai, Eric Oldfield, Steven C. Zimmerman, Yugang Bai,* and Xinxin Feng,* A Polymeric Approach toward Resistance-Resistant Antimicrobial Agent with Dual-Selective Mechanisms of Action. Sci. Adv. 2021, 7, eabc9917. [Link]

[21] Ying Liu, Yugang Bai,* Design and Engineering of Metal Catalysts for Bioorthogonal Catalysis in Living Systems. ACS Appl. Bio Mater. 2020, 3, 4717. [Link]

[20] Yugang Bai, Hang Xing, Yunhao Bai, Li Huey Tan, Kevin Hwang, Ji Li, Yi Lu*, and Steven C. Zimmerman,* Independent Control over Size, Valence, and Elemental Composition in the Synthesis of DNA-Nanoparticle Conjugates. Chem. Sci. 2020, 11, 1564. [Link]

[19] Qing Lu, Silei Bai, Zhiyong Chen, Nan Zheng, Xinxin Feng, Yugang Bai*, A Dense-Shell Macromolecular Scaffold for Catalyst- or Substrate-Guided Catalysis in a Cellular Environment. ACS Materials Lett. 2020, 2, 89. [Link]

[18] Zhiyong Chen, Wei Huang, Nan Zheng*, Yugang Bai*, Design and Synthesis of a Polyguanidium Vector with Enhanced DNA Binding Ability for Effective Gene Delivery at a Low N/P Ratio. Polym. Chem. 2020, 11, 664. [Link]

[17] Nan Zheng, Dan Xie, Chunsen Wang, Zhiyi Zhang, Yubin Zheng, Qing Lu, Yugang Bai, Yang Li, Aiguo Wang*, Wangze Song*, Water-Soluble, Zwitterionic Poly-Photosensitizers as Carrier-Free, Photosensitizer-Self-Delivery System for in Vivo Photodynamic Therapy. ACS Appl. Mater. Interfaces 2019, 11, 44007.  [Link]

[16] Nan Zheng, Zhiyi Zhang, Jia Kuang, Chunsen Wang, Yubin Zheng, Qing Lu, Yugang Bai, Yang Li, Aiguo Wang, Wangze Song*, Poly (photosensitizers) Nanoparticles for Enhanced In Vivo Photodynamic Therapy by Interrupting the π-π Stacking and Extending Circulation Time. ACS Appl. Mater. Interfaces 2019, 11, 18224. [Link]

[15]  JuYeon Lee, Yugang Bai, Ullas V. Chembazhi, Shaohong Peng, Kevin Yum, Long M. Luu, Lauren D. Hagler, Julio F. Serrano, H. Y. Edwin Chan, Auinash Kalsotra*, and Steven C. Zimmerman*, Intrinsically cell-penetrating multivalent and multitargeting ligands for myotonic dystrophy type 1. Proc. Natl. Acad. Sci. U. S. A. 2019116, 8709. [Link]

[14] Yue Xiao, Yang Li, Bohan Zhang, Hui Li, Zehong Cheng, Jianqiao Shi, Jing Xiong, Yugang Bai, and Ke Zhang*, Functionalizable, Side Chain-Immolative Poly(benzyl ether)s. ACS Macro Lett. 2019, 8, 399. [Link]

As a graduate student or postdoc:

[13] Junfeng Chen, Jiang Wang, Yugang Bai, Ke Li, Edzna S. Garcia, Andrew L. Ferguson, and Steven C. Zimmerman*, Enzyme-like Click Catalysis by a Copper-Containing Single-Chain Nanoparticle. J. Am. Chem. Soc. 2018, 140, 13695. [Link]

[12] Ying Li, Katharina Huth, Edzna S. Garcia, Benjamin J. Pedretti, Yugang Bai, Gretchen A. Vincil, Rainer Haag and Steven C. Zimmerman*, Linear dendronized polyols as a multifunctional platform for a versatile and efficient fluorophore design. Polym. Chem. 2018, 9, 2040. [Link]

[11]    Yugang Bai, Junfeng Chen and Steven C. Zimmerman*, Designed transition metal catalysts for intracellular organic synthesis. Chem. Soc. Rev. 2018, 47, 1811. [Link]

[10]   Hang Xing, Yugang Bai, Yunhao Bai, Li Huey Tan, Jing Tao, Benjamin J. Pedretti, Gretchen A. Vincil, Yi Lu*, and Steven C. Zimmerman*, Bottom-up strategy to prepare nanoparticles with a single DNA strand. J. Am. Chem. Soc. 2017, 139, 3623. [Link]

[9]   Yugang Bai, Xinxin Feng, Hang Xing, Boo Kyung Kim, Noman Baig, Tianhui Zhou, Andrew Gewirth, Yi Lu, Eric Oldfield and Steven C. Zimmerman*, A highly efficient single-chain metal-organic nanoparticle catalyst for alkyne-azide “Click” reactions in water and in cells. J. Am. Chem. Soc. 2016, 138, 11077. [Link] This paper was recommended by F1000Prime.

[8]   Yugang Bai, Lien Nguyen, Ziyuan Song, Shaohong Peng, JuYeon Lee, Nan Zheng, Iti Kapoor, Lauren D. Hagler, Kaimin Cai, Jianjun Cheng, H. Y. Edwin Chan, and Steven C. Zimmerman*, Integrating display and delivery functionality with a cell penetrating peptide mimic as a scaffold for intracellular multivalent multi-targeting. J. Am. Chem. Soc. 2016, 138, 9498. [Link]

[7]   Ying Li, Yugang Bai, Nan Zheng, Yang Liu, Gretchen A. Vincil, Benjamin J. Pedretti, Jianjun Cheng and Steven C. Zimmerman*, Crosslinked dendronized polyols as a general approach to brighter and more stable fluorophores. Chem. Commun. 2016, 52, 3781. [Link]

[6]   Yugang Bai, Hang Xing, Peiwen Wu, Xinxin Feng, Jennifer M. Lee, Xin Yi Phang, Yi Lu and Steven C. Zimmerman*, Chemical control over cellular uptake of organic nanoparticles by fine tuning surface functional groups. ACS Nano 2015, 9, 10227. [Link]

[5]   Hua He, Yugang Bai, Jinhui Wang, Qiurong Deng, Lipeng Zhu, Fenghua Meng, Zhiyuan Zhong, and Lichen Yin*, Reversibly cross-linked polyplexes enable cancer-targeted gene delivery via self-promoted DNA release and self-diminished toxicity. Biomacromolecules 2015, 16, 1390. [Link]

[4]  Yugang Bai, Hang Xing, Gretchen A. Vincil, Jennifer Lee, Essence J. Henderson, Yi Lu, N. Gabriel Lemcoff and Steven C. Zimmerman*, Practical synthesis of water-soluble organic nanoparticles with a single reactive group and a functional carrier scaffold. Chem. Sci. 2014, 5, 2862. [Link]

[3]  Yugang Bai, Hua Lu, Ettigounder Ponnusamy and Jianjun Cheng*, Synthesis of hybrid block copolymers via integrated ring-opening metathesis polymerization and polymerization of NCA. Chem. Commun. 2011, 47, 10830. [Link]

[2]  Hua Lu, Yugang Bai, Jing Wang, Nathan P. Gabrielson, Fei Wang, Yao Lin and Jianjun Cheng*, Ring-opening polymerization of γ-(4-vinylbenzyl)-L-glutamate N-carboxyanhydride for the synthesis of functional polypeptides. Macromolecules 2011, 44, 6237. [Link]

[1] Hua Lu, Jing Wang, Yugang Bai, Jason W. Lang, Shiyong Liu, Yao Lin and Jianjun Cheng*, Ionic polypeptides with unusual helical stability. Nat. Commun. 2011, 2, 206. [Link]